3-[((2R)-1-methylpyrrolidin-2-yl)methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole
3-[((2R)-1-methylpyrrolidin-2-yl)methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole
CAS: 180637-89-2
Molecular Formula: C22H24N2O2S
3-[((2R)-1-methylpyrrolidin-2-yl)methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole - Names and Identifiers
| Name | 3-[((2R)-1-methylpyrrolidin-2-yl)methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole |
| Synonyms | Eletriptan Impurity 23 (R)-3-((1-Methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indole (R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole 3-[((2R)-1-methylpyrrolidin-2-yl)methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole 3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE (R)-3-[(1-Methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethenyl]-1H-indole 3-[[(2R)-1-Methyl-2-pyrrolidinyl]Methyl]-5-[2-(phenylsulfonyl)ethenyl]-1H-indole 1H-Indole, 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethenyl]- 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5-[(E)-2-(phenylsulfonyl)ethenyl]-1H-indole |
| CAS | 180637-89-2 |
| InChI | InChI=1/C22H24N2O2S/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20/h2-4,7-11,13-14,16,19,23H,5-6,12,15H2,1H3/b13-11+/t19-/m1/s1 |
3-[((2R)-1-methylpyrrolidin-2-yl)methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole - Physico-chemical Properties
| Molecular Formula | C22H24N2O2S |
| Molar Mass | 380.5 |
| Density | 1.263 |
| Boling Point | 617.7±55.0 °C(Predicted) |
| Flash Point | 327.4°C |
| Vapor Presure | 3.46E-15mmHg at 25°C |
| pKa | 16.92±0.30(Predicted) |
| Refractive Index | 1.655 |
3-[((2R)-1-methylpyrrolidin-2-yl)methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole - Introduction
3-[((2R)-(2R)-) methyl]-5-[(E)-(phenylsulfonyl)vinyl]indole is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
3-[(2R)-methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole is a solid compound. Its molecular formula is C25H21N3O2S and its molecular weight is 419.52g/mol. It has a higher melting point and boiling point, is soluble in some organic solvents such as ethanol and dimethyl sulfoxide compounds.
Use:
The compound has potential application value in the field of drug research. It is widely used as an intermediate in drug synthesis and can be used to synthesize biologically active compounds.
Method:
The preparation of 3-[(2R)-methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole can be completed by a synthetic route. The specific preparation method may involve three main steps:(1) the reaction of pyrrolidone and methyl thioketone to produce 1-methyl -2-pyrrolidinyl methyl sulfur,(2) 1-Methyl-2-pyrrolidinylmethylsulfide reacts with styrene sulfonyl chloride to give (R)-3-(1-methyl-2-pyrrolidinyl) methyl]-5-[2-(phenylsulfonyl) vinyl]-LH-indole,(3) The resulting product was purified and crystallized using the corresponding reaction conditions.
Safety Information:
When handling this compound, appropriate safety measures need to be taken. Since 3-[((2R)-(2R)) methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole may be irritating to the skin and eyes, proper protective glasses, gloves and laboratory clothing are recommended. In addition, to avoid inhaling the dust of the compound, please operate in a well-ventilated environment. Laboratory safety guidelines should also be followed when using the compound, and waste should be stored and disposed of properly.
Nature:
3-[(2R)-methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole is a solid compound. Its molecular formula is C25H21N3O2S and its molecular weight is 419.52g/mol. It has a higher melting point and boiling point, is soluble in some organic solvents such as ethanol and dimethyl sulfoxide compounds.
Use:
The compound has potential application value in the field of drug research. It is widely used as an intermediate in drug synthesis and can be used to synthesize biologically active compounds.
Method:
The preparation of 3-[(2R)-methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole can be completed by a synthetic route. The specific preparation method may involve three main steps:(1) the reaction of pyrrolidone and methyl thioketone to produce 1-methyl -2-pyrrolidinyl methyl sulfur,(2) 1-Methyl-2-pyrrolidinylmethylsulfide reacts with styrene sulfonyl chloride to give (R)-3-(1-methyl-2-pyrrolidinyl) methyl]-5-[2-(phenylsulfonyl) vinyl]-LH-indole,(3) The resulting product was purified and crystallized using the corresponding reaction conditions.
Safety Information:
When handling this compound, appropriate safety measures need to be taken. Since 3-[((2R)-(2R)) methyl]-5-[(E)-2-(phenylsulfonyl)vinyl]indole may be irritating to the skin and eyes, proper protective glasses, gloves and laboratory clothing are recommended. In addition, to avoid inhaling the dust of the compound, please operate in a well-ventilated environment. Laboratory safety guidelines should also be followed when using the compound, and waste should be stored and disposed of properly.
Last Update：2024-04-09 20:52:54
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